Acute Kidney Injury (AKI)

BackgroundAKI is a common clinical entity associated with high morbidity and mortality. The clinical syndrome characterized by a rapid (hours to days) decrease in renal excretory function, with the accumulation of nitrogen metabolic products such as creatinine and urea. The pathophysiology of AKI is multifaceted, involving hemodynamic alterations, inflammation, and endothelial and epithelial cell injury.

Model: Renal arterial ischemia induced AKI 

Standard study duration: 4 weeks

Clinical endpoint: Renal function, urine volume, glomerular filtration rate (GFR), histopathology…

Features: Ischemic time-dependent severity, human-like disease prograession, biomarkers, chronic disease studies (such as AKI to CKD, cardio-renal syndrome etc.)…


For more information about these models, please contact Mr. James Song, mailto:james.song@prisysbiotech.com

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