Nonalcoholic Steatohepatitis (NASH)

Background: NASH is a progressive liver disorder that occurs in patients without significant alcohol consumption, and, histologically, it resembles the alcoholic liver disease with macrovesicular steatosis, spotty necrosis, inflammation, and fibrosis. The “two-hit theory” provides the mostly acceptable explanation for the progression of NASH. 

Model: Liver metabolic disorder combined with inflammation, oxidative stress or hepatotoxin induced NASH

Standard study duration: 24 weeks

Clinical endpoint: Liver function index, B-ultrasound, liver biopsy, NASH clinical scoring…

Features: Same human clinical symptoms and metabolic disorders, secondary diseases, gradually disease development…

Status: Open for Co-development

For more information about these models, please contact Mr. James Song,