Ischemic Stroke/MCAO

Background:Ischemic stroke is the most common disease in brain. It occurs when blood supply to part of the brain is restrained in the cerebrovasculature, leading to dysfunction of the local brain tissue.

Model: Middle cerebral artery (MCA) occlusion with craniotomy/trans-orbital surgery/clot embolization/microsphere embolization/DSA techniques

Standard study duration: 4-8 weeks

Clinical endpoints: Neurologic deficit score, magnetic resonance image (MRI), cerebral infarct size, cerebral blood flow (PET), physiological parameters (BP, HR, Body Tm), histopathology…

Features: Human similar brain structure, clinical score, high survival rate, thrombolytic treatments….

 

Background:In contrast to rodent and other non-primate stroke models that have inherent flaws, nonhuman primate models of focal ischemic stroke provide excellent opportunities for understanding the vascular and cellular pathophysiology of cerebral ischemic injury because they resemble what happens in humans. In addition to being used for neuroprotective assessment, these models can also facilitate efforts to develop diagnostic tools for identifying and treating stroke symptoms.

Model: intraluminal technique induced middle cerebral artery occlusion (reversible and irreversible)

Standard study duration: 4 weeks

Clinical endpoint: DSA, MRI, Neurological assessment, histology

Features: nerve regeneration, brain injury, infarction, stroke, interventional therapy, neuroimaging

 

For more information about these models, please contact Mr. James Song, mailto:james.song@prisysbiotech.com

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