Ischemic Stroke/MCAO
Background:Ischemic
stroke is the most common disease in brain. It occurs when blood supply to part
of the brain is restrained in the cerebrovasculature, leading to dysfunction of
the local brain tissue.
Model: Middle cerebral artery (MCA) occlusion with
craniotomy/trans-orbital surgery/clot embolization/microsphere embolization/DSA
techniques
Standard study duration: 4-8 weeks
Clinical endpoints: Neurologic deficit
score, magnetic resonance image (MRI), cerebral infarct size, cerebral blood
flow (PET), physiological parameters (BP, HR, Body Tm),
histopathology…
Features: Human similar brain structure,
clinical score, high survival rate, thrombolytic treatments….
Background:In contrast to rodent and other non-primate stroke models that have
inherent flaws, nonhuman primate models of focal ischemic stroke provide
excellent opportunities for understanding the vascular and cellular pathophysiology of cerebral ischemic injury because they resemble
what happens in humans. In addition to being used for neuroprotective
assessment, these models can also facilitate efforts to develop diagnostic
tools for identifying and treating stroke symptoms.
Model: intraluminal technique induced
middle cerebral artery occlusion (reversible and irreversible)
Standard study duration: 4 weeks
Clinical endpoint: DSA, MRI, Neurological
assessment, histology
Features: nerve regeneration, brain injury,
infarction, stroke, interventional therapy, neuroimaging
For more information about these models,
please contact Mr. James Song, mailto:james.song@prisysbiotech.com