Background：Temporal lobe epilepsy (TLE) with hippocampal sclerosis is the most common type of drug-resistant epilepsy. Non-human primates are attractive models for studying the pathogenic mechanisms of TLE, with the goal of developing new drugs and interventions

Model: unilateral hippocampal injections induced repetitive acute seizures

Standard study duration: 12-16 weeks

Clinical endpoint: video analysis of behaviors, EEG, object retrieval test, brain MRI…

Features: TLE, temporal lobe epilepsy; spontaneous recurrent seizures; EEG, electroencephalography; SREDs, spontaneous recurrent epileptiform discharges

Status: Open for Co-development