Background：acute liver injury (ALI) refers to patients with coagulopathy and no signs of encephalopathy. Its occurrence following Amanita phalloides mushroom poisoning is well known with the associated morbidity, mortality and often the need for liver transplantation in a significant proportion of cases.

Model: LPS induced ALI

Standard study duration: 2 weeks

Clinical endpoint: AST, ALT, liver biopsy, ultrasound

Features: stable incidence, multiple and controlled injury cycle, targeted delivery of LPS