Background：Sjögren‘s syndrome (Sicca syndrome, SS) is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. With this disorder, the body's immune system attacks its own healthy cells that produce saliva and tears.

Model: Synthetic M3R peptide induced SS

Standard study duration: 8-10 weeks

Clinical endpoint:

•        Clinical observation (Oral and ocular examination)

•        Pilocarpine induced salivary and tear secretion

•        Water intake and consumption

•        Salivary biopsy and histopathology

•        Endoscopy (Trachea and digestive tract)

Features: rare disease, human clinical examinations, human-similar disease development

Status: Open for Co-development